IRS1 anticorps (pSer312)

N° du produit ABIN7138549

Cet anticorps anti-IRS1 est un anticorps Lapin Polyclonal détectant IRS1 dans WB et ELISA. Adapté pour Humain.

Aperçu rapide pour IRS1 anticorps (pSer312) (ABIN7138549)

Antigène: IRS1 (Insulin Receptor Substrate 1 (IRS1))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp IRS1 est non-conjugé

Application: Western Blotting (WB), ELISA

Détail du produit anti-IRS1 anticorps

Épitope: pSer312

Fonction: Phospho-IRS1 (Ser312) Antibody

Réactivité croisée: Souris, Rat

Purification: Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.

Immunogène: Peptide sequence around phosphorylation site of serine 312 (A-T-S(p)-P-A) derived from Human IRS-1.

Isotype: IgG

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Supplied at 1.0 mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur IRS1

Antigène: IRS1 (Insulin Receptor Substrate 1 (IRS1))

Autre désignation: IRS1

Sujet:

Background: May mediate the control of various cellular processes by insulin. When phosphorylated by the insulin receptor binds specifically to various cellular proteins containing SH2 domains such as phosphatidylinositol 3-kinase p85 subunit or GRB2. Activates phosphatidylinositol 3-kinase when bound to the regulatory p85 subunit

Tzatsos A, et al. (2006) Mol Cell Biol, 26(1): 63-76
Ozes ON, et al. (2001) Proc Natl Acad Sci U S A, 98(8): 4640-4645
Szanto I, et al. (2000) Proc Natl Acad Sci U S A, 97(5): 2355-2360
Ozes ON, et al. (2001) Proc Natl Acad Sci U S A, 98(8): 4640-4645

Aliases: HIRS 1 antibody, HIRS1 antibody, Insulin receptor substrate 1 antibody, IRS 1 antibody, IRS-1 antibody, IRS1 antibody, IRS1_HUMAN antibody, OTTHUMP00000164234 antibody

UniProt: P35568

Pathways: Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Positive Regulation of Peptide Hormone Secretion, Hormone Transport, Negative Regulation of Hormone Secretion, Response to Growth Hormone Stimulus, Carbohydrate Homeostasis, Regulation of Carbohydrate Metabolic Process